Showing posts with label light. Show all posts
Showing posts with label light. Show all posts

Wednesday, June 29, 2011

Light pulse flips gene switch

24 June 2011 Last updated at 14:42 GMT By Jennifer Carpenter Science reporter, BBC News Cells getting light treatment (Image: Science) LEDs deliver a long pulse of blue-light to mammalian cells to turn on these little protein factories. Scientists have developed a technique that could be used to deliver precise doses of hormones to people who don't make them naturally.

To do this, they rewired kidney cells with light-sensitive molecules from the eye, they reported in the journal Science.

When pulsed with blue light, these cells churned out proteins on demand.

Ultimately, this technique could avoid the need for people with diabetes to inject themselves regularly.

"When I speak to diabetes patients they say that if you could take away always having to inject themselves it would really increase their quality of life," said lead author Martin Fussenegger, a bioengineer of the Swiss Federal Institute of Technology, Zurich.

Dr Fussenegger thought he saw a solution in his own field of optogenetics. Optogenetics, as the name suggests, uses light to control the behaviour cells.

To get a cell to respond to light you first have to rejigger it so it has a light-sensitive molecule on its surface. Dr Fussenegger coaxed kidney cells to express melanopsin, a molecule usually found in animals' eyes.

Blue genes

He then placed these cells into diabetic mice. Along with the cells he placed an optic fibre, down which he could pulse blue light to expose the cells at his command.

In the dark, these cells behaved as usual; In the light, however, genes in the cell were switched on and the cell pumped out a protein required for the breakdown of sugars in the blood, helping the mice to control their glucose levels.

He hopes that cells like these could ultimately be implanted into people, and exposed to light - either through the skin or down a optic fibre - to release proteins that would help treat diabetes.

The new technique is a proof of principle. He told BBC News that it was not limited to treating diabetes; this technology could be usedto switch on genes to produce many different proteins in people who do not make them naturally, or are not making enough of them to be healthy.

Light switch

"I think this is a phenomenal research tool," said James Collins, a synthetic biologist at Howard Hughes Medical Institute, Maryland, US, who was not involved in the work.

Dr Collins explained that as we move into an age of regenerative medicine, and begin to think of how we use stem cells to produce different tissues in the body, one of the challenges will be to work out which genes are needed to produce certain tissues and cells.

This new technique allows researchers to switch genes on and off to determine which are essential to make a specific tissues.


View the original article here

Sunday, June 19, 2011

Heat and light

16 June 2011 Last updated at 14:54 GMT Sun observed by the Soho satellite The Sun appears to be calming but that does not necessarily mean cooling on Earth Over the last few years, the politics of climate change have been amply forged in the fires of a changeable Sun.

And the story is here again, in the form of research unveiled this week at a meeting of the American Astronomical Society (AAS) Solar Physics Division in Las Cruces, New Mexico.

The solar science, described graphically in a Discover Magazine post - "an east/west river of gas" which "flows under the surface of the Sun" that can't be seen directly but which is inferred from "sound waves that travel from it to the surface" - is fascinating.

And what it suggests is that the Sun appears set to quieten further over the next solar cycle than it already has - with lower sunspot activity, and perhaps marginally lower energy output.

But as to the implications on Earth - well, for anyone who's followed this story for a while, they're very familiar, and the telling of them is laced with equally familiar political overtones.

The big question is this: if the predictions of an impending reduction in solar activity turn into reality, what would that mean for the global climate?

And that's why it becomes a political football - because if the answer is that it counteracts global warming, still more if it leads to global cooling, then moves away from fossil fuel use are at best unnecessary and at worst harmful.

The comparator here is the Maunder Minimum - a period of low solar activity running in the late 1600s and early 1700s - a "grand solar minimum" - which co-incided with a period of colder than usual temperatures - at least, in parts of Europe.

So you can probably name a few organisations likely to pounce on this latest work as evidence that another cool period is coming, and that society's logical response is to drill, baby, drill and burn, baby, burn like never before.

The Register doesn't disappoint, suggesting the solar cycle predictions will become "the science story of the century" and mean that the Earth is "heading into a mini Ice Age" - while the Daily Telegraph's James Delingpole treats it as fact - "It's official: a new Ice Age is on its way".

Representation of Earth covered in ice The Earth may have been a "snowball" once but an imminent repeat seems unlikely

As it has been for years, the reality is rather different.

Firstly, the research itself has been presented at one rather small and rather select science meeting - not, as yet, formally published and peer reviewed.

Soundings taken by dot.earth's Andy Revkin suggest that not everyone in the solar physics community likes what they've seen - so publication could yet prove a hurdle.

Secondly, the predictions made about the next solar cycle would have to turn into reality - which might not happen, however sound the science.

Thirdly, even if all that happens, the Sun's activity would have to diminish enough to overwhelm the man-made contribution to the greenhouse effect.

Four years ago, in the midst of the Intergovernmental Panel on Climate Change's last major assessment of global climate and shortly after Henrik Svensmark's The Chilling Stars elaborated how the Earth's modern climate could be determined by solar effects on cosmic rays, I looked into this question for a feature article on this website - part of a series on scientific, social and political aspects of "climate scepticism".

The conclusions, in a nutshell, were these:

The Sun is the major determinant of the Earth's climate on long timescalesCosmic rays have been a mediator of this effectIt is not the major issue on human timescalesAny effect from modern changes in solar activity is likely to be dwarfed by greenhouse gas emissions and associated issues such as sulphate aerosols.

That was four years ago; and since then, further research published in peer-reviewed journals has, if anything, weakened the solar case - whether involving cosmic rays or not.

Research on cloud formation in the real world suggests the cosmic ray amplification of cloud cover - the way the Svensmark idea works - isn't big enough.

A recent modelling exercise on the impact of any future grand minimum suggested it would cool the planet by a fraction of a degree Celsius.

Another recent paper concluded that while the major Ice Ages occurring every 100,000 are undoubtedly profound events, the so-called Little Ice Age that partially co-incided with the Maunder Minimum wasn't anything like that, bringing temperatures down globally by 0.3-0.4C.

Cosmic ray tracks Changes in cosmic ray flux have altered climate in the past, but do not seem to be dominant now

Since the beginning of the industrial era, by comparison, temperatures have risen by about 0.7C.

Joanna Haigh, a solar physicist at Imperial College London, has spent a fair bit of research time investigating mechanisms that could potentially amplify solar changes into meaningful temperature variations on human timescales on Earth.

She summed up the importance of the latest research like this:

"In a future grand minimum, the Sun might perhaps again cool the planet by up to 1C.

"Greenhouse gases, on the other hand, are expected to raise global temperatures by 1.5-4.5C by 2100.

"So even if the predictions are correct, the effect of global warming will outstrip the Sun's ability to cool even in the coldest scenario.

"And in any case, the cooling effect is only ever temporary. When the Sun's activity returns to normal, the greenhouse gases won't have gone away."

She could have added that changes in solar output have no impact on ocean acidification, the other major impact of rising carbon dioxide concentrations.

Scientific research progresses; and occasionally something that appears to be solid gets overturned by a stunning new discovery.

It may be about to happen in particle physics - if neither the Tevatron nor Large Hadron Collider spots a Higgs boson soon, the standard model that scientists have worked with for years may have to be abandoned, or at least seriously reformed, and another built in its place.

And yes, the same thing could happen with man-made global warming.

But it hasn't yet.

All the studies I'm referring to above are out there in the public domain - which immediately raises a question over why some accounts claim big things for the new research but fail to take into account the context afforded by the larger body of published work.

The battle for public opinion on climate change is largely fought with memes; and solar changes leading to a cooling planet is one of them.

On this battleground, where the bigger picture can be conveniently forgotten, it has proven remarkably persistent.

Part of its appeal is that it has some scientific grounding; but it melts away in the light of the bigger research picture, and that's why it has little credence in mainstream scientific circles as a major factor in modern-day temperature fluctuations.


View the original article here